Quick Answer: Does Metolazone Cause Hypokalemia?

Low sodium and potassium levels warning: In rare cases, taking metolazone has suddenly led to low sodium levels (hyponatremia) or low potassium levels (hypokalemia) or both. If this occurs, your doctor may have you stop using metolazone.

How does metolazone affect potassium?

Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking “loop” diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ).

What are the side effects of metolazone?

Metolazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• dizziness.
• weakness.
• restlessness.
• headache.
• muscle cramps.
• joint pain or swelling.
• constipation.
• diarrhea.

Which diuretic causes the most hypokalemia?

Because loop and thiazide diuretics increase sodium delivery to the distal segment of the distal tubule, this increases potassium loss (potentially causing hypokalemia) because the increase in distal tubular sodium concentration stimulates the aldosterone-sensitive sodium pump to increase sodium reabsorption in

Can metolazone cause hyponatremia?

Metolazone was strongly associated with hyponatremia, hypokalemia, and worsening renal function (P<0.0001 for all) with minimal effect attenuation following covariate and propensity adjustment.

Does metolazone increase potassium?

Although metolazone does not have the same structure as the other thiazide diuretics, it increases the excretion of sodium, potassium, and water by inhibiting sodium reabsorption in the distal and proximal convoluted tubule.

Why do you give metolazone 30 minutes before furosemide?

Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.

Is metolazone hard on the kidneys?

For people with gout: Metolazone can increase the amount of acid in your body. This can cause gouty attacks. For people with kidney disease: Metolazone is eliminated from your body through your kidneys and can build up in your body if your kidneys aren’t working as well as they should. This can lead to toxicity.

Is metolazone stronger than furosemide?

The mean reduction in body weight was 6.1 kg (2 p less than 0.001) within 7 days of continuous treatment. Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention.

Can you take metolazone everyday?

Metolazone is usually taken only once per day. You may need to limit salt in your diet while taking this medicine. Follow your doctor’s instructions carefully. While using metolazone, you may need frequent blood tests.

Which diuretics are potassium wasting?

Thiazide diuretics, such as chlorothiazide (Diuril), chlorthalidone (Hygroton), and hydrochlorothiazide (Esidrix, HydroDiuril, Microzide) tend to deplete potassium levels. So do loop diuretics, such as bumetanide (Bumex) and furosemide (Lasix).

Does Lasix cause hypokalemia?

As with many diuretics, it can cause dehydration and electrolyte imbalance, including loss of potassium, calcium, sodium, and magnesium. Excessive use of furosemide will most likely lead to a metabolic alkalosis due to hypochloremia and hypokalemia.

Is Bumex potassium wasting?

Is Bumex potassium wasting? Bumex is a potent diuretic that can increase urinary output of excess fluid. By the same token, the use of Bumex can lead to a loss of fluid and electrolytes. As a result, Bumex can increase the excretion of potassium from the body.

Does Metolazone increase sodium?

Metolazone works by inhibiting sodium transport across the epithelium of the renal tubules (mostly in the distal tubules), resulting in a decrease in sodium reabsorption and an increase in sodium, chloride, and water excretion.

Which diuretic causes Hypernatremia?

The drug of choice for diuresis has traditionally been furosemide. However, this drug cause hypernatremia (a rise in serum sodium) in a significant proportion of patients.

Do diuretics cause hypernatremia or hyponatremia?

Hyponatremia. Hyponatremia is an uncommon, but serious, complication of diuretic therapy. Thiazide diuretics are more likely than loop diuretics to cause hyponatremia. Loop diuretics inhibit sodium (Na⁺) transport in the renal medulla and prevent the generation of a maximal osmotic gradient.